Inter-device Reliability of Swept Source and Spectral Domain Optical Coherence Tomography Retinal Structure Measurements in Schizophrenia

Swetha Gandu, BS

Beth Israel Deaconess Medical Center
nter-device Reliability of Swept Source and Spectral Domain Optical Coherence Tomography Retinal Structure Measurements in Schizophrenia

Scientific Abstract

Background: Optical coherence tomography (OCT) is used to study retinal structure in schizophrenia. Various generations of OCT are utilized in studies, which may introduce measurement variability. We investigated the inter- and intra-device agreement of macular thickness in schizophrenia, and macula and peripapillary group differences in schizophrenia using swept source OCT (SS-OCT).

Methods: Macular OCT thickness was obtained for schizophrenia (n=30) and healthy controls (HC, n= 22) using spectral domain OCT (SD-OCT) and SS-OCT. Peripapillary thickness was obtained using SS-OCT. Retinal nerve fiber layer (RNFL), ganglion cell-inner plexiform complex (GCL+), RNFL-GCL+ (GCL++), and macular thickness was collected. Symptom ratings and cognitive data were gathered. Statistical analyses were performed using R software.

Results: High inter-scanner relative and absolute agreement for GCL+ and GCL++, with ICC’s between r =0.84-0.99. Moderate to excellent intra-scanner relative and absolute ICC was observed in all measures except macular RNFL SS-OCT for HC (r=0.39). No significant group differences were identified for macular or peripapillary layer measures. Overall cognition (BACS composite score) was inversely associated with peripapillary retinal thickness (r=0.32, p=0.04). Poor verbal fluency was correlated with peripapillary total retinal layer thinning (r=0.37,p=0.01) and RNFL thinning(r=0.31, p=0.04).

Conclusion: These findings demonstrate a high level of consistency among SD- and SS-OCT scanners for the GCL+, GCL++, with greater variability for total retinal and RNFL thickness.

Because of the strong literature implicating RNFL thinning in schizophrenia and our finding showing association to cognition, this finding suggests intra-scanner measures are appropriate, but caution should be taken in multi-vendor scanner studies.

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research Areas

Authors

Swetha Gandu, BS, Deepthi Bannai, MS,Megan Kasetty,MD Scot Hill,,PhD, Leo A. Kim,MD,PhD Brett Clementz, PhD,Elliot Gershon,MD,Godfrey Pearlson, MD, Sarah Keedy,PhD, Carol Tamminga, MD,John Miller,MD, Matcheri Keshavan, MD, Paulo Lizano MD,PhD

Principal Investigator

Paulo Lizano MD, PhD

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