Peripheral Inflammatory Markers Are Associated with Neural Activity During the Auditory Oddball Task

Nicolas Raymond, BA

Beth Israel Deaconess Medical Center
Peripheral Inflammatory Markers Are Associated with Neural Activity During the Auditory Oddball Task

Scientific Abstract

Background: Electroencephalographic (EEG) abnormalities and inflammation have been independently associated with schizophrenia spectrum disorders. Pre-clinical studies have linked inflammation with event-related potentials (ERP), but studies examining time-frequency relationships, which capture complex neural dynamics, are limited. Here, we aim to investigate the role of peripheral inflammation with ERP and time-frequency measures in idiopathic psychosis.

Methods: Serum cytokines were measured for IL-6, TNFa, and CRP from 175 persons with idiopathic psychosis or from healthy volunteers. The auditory oddball task was recorded using high density EEG. Subjects were asked to press a button on a response pad when a target stimulus was detected. ERP and time-frequency analyses were derived from principal component analysis. Pearson’s correlations were performed and an FDR threshold of p<0.10 was set.

Results: Higher IL-6 was associated with higher N100 (r=0.21, padj=0.09) and P200 (r=0.20, padj=0.09) voltage for target stimuli. Higher TNFa was correlated with greater event-related oscillatory responses in mid-range beta for the standard tone (r=0.21, padj=0.09). Greater CRP and IL-6 levels were associated with smaller low frequency oscillatory responses for the standard tone (r=-0.20, padj=0.09; r=-0.21, padj=0.09, respectively).

Conclusion: Our findings suggest that inflammation could influence certain neuronal networks and processes related to the auditory oddball task. Specifically, IL-6, CRP and TNFa correlate with neural measures related to early information processing as well as measures related to long range, cortico-cortical communication.

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research Areas


Nicolas Raymond, BA, Matthew Hudgens-Haney, Phd, Adam Lee, PhD, Sarah Keedy, Phd, Carol Tamminga, MD, Godfrey Pearlson,MD, Elliot Gershon, MD, John Sweeney, PhD, Matcheri Keshavan, MD, Brett Clementz, Phd, Jeffrey Bishop, PhD, Paulo Lizano, MD, PhD

Principal Investigator

Paulo Lizano, MD, PhD