The Relationship between Cigarette Smoking and Mood Symptoms in a Physical Activity Trial

Doga Cetinkaya, BS Candidate

Massachusetts General Hospital – Clinical Research Intern

Scientific Abstract

Background: Cigarette smoking is prevalent among individuals with bipolar disorder (BD) compared to those without BD. Moreover, cigarette smoking has negative health consequences, including poor cardiovascular health. To our knowledge, there are few studies that have evaluated the relationship between mood symptoms and cigarette smoking among individuals with lifetime mood episodes and cardiovascular risk. Therefore, we examined baseline characteristics of past-year cigarette smokers with lifetime mood episodes and cardiovascular risk who were enrolled in a physical activity trial.

Methods: Participants were recruited from two online PCORI-funded communities: Mood- Network and Health-eHeart Alliance. Eligible participants had a lifetime history of depression and were at risk for cardiovascular disease (defined as < 150 minutes of physical activity per week). Participants completed self-report questionnaires assessing lifetime psychiatric symptoms, depressive symptoms, and hypomanic symptoms. Participants were considered to be past-year cigarette smokers if they self-reported “yes” to: In the past year, have you ever smoked cigarettes regularly?” We conducted t-tests to compare mean depressive and (hypo)manic symptoms between past-year smokers and non-smokers.

Results: Past-year cigarette smokers reported higher levels of depression and (hypo)mania on the PHQ-9 and ASRM ( M= 13.5, SD = 5.9; M = 2.9, SD = 3.0) relative to past year non-smokers   (M = 11.7, SD = 5.6; M = 1.9, SD = 2.3). Additionally, a greater percentage (63.6%, n=28/44) of past-year cigarette smokers compared to non past-year cigarette smokers (51.8%, n = 214/413) reported experiencing lifetime (hypo)mania.

Conclusions: Past-year cigarette smokers had higher mean depressive and (hypo)manic symptoms relative to non past-year smokers. The majority of past-year cigarette smokers reported experiencing (hypo)mania in their lifetime.


Live Zoom Session – March 9th

research Areas


Doga Cetinkaya, Angela Salisbury, Alexandra K. Gold, MA, Yunfeng Deng, BA, Caylin M. Faria, BS, Matan S. Levine-Janach, BA, Bilal Wurie, BA, Amy T. Peters, PhD, Douglas Katz, PhD Andrew A. Nierenberg, MD, Louisa G. Sylvia, PhD

Principal Investigator

Louisa Sylvia, PhD and Andrew A. Nierenberg, MD

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