Background: We previously characterized the brain structural connectivity across inflammatory subtypes in patients with first-episode psychosis, however, few attempts have been made at identifying structural connectivity in this population over time. Thus, we aimed to examined brain topology differences at baseline and one year of follow-up in healthy controls (HC) and individuals with FEP.
Methods: MRI scans were obtained for FEP-schizophrenia (FEP-SZ, n=17), FEP non-schizophrenia (FEP-NSZ, n=13), and healthy controls (HC, n=29) at baseline and after 1 year using Freesurfer version 6.0. Gray matter thicknesses and subcortical volumes were adjusted for age, sex, race, socioeconomic status, and intracranial volume (for subcortical measures only) and graph-theoretically analyzed to assess global and local network properties across diagnostic groups.
Results: Regarding global networks, FEP-SZ individuals experience a statistically significant reduction in global efficiency over time while HC individuals exhibit a statistically significant increase in local efficiency over time. Regarding regional network topology, overall, FEP-SZ and FEP-NSZ individuals demonstrated the most changes across all three measures of segregation, integration, and centrality compared to HC and FEP. Specifically, for the measure of centrality, FEP-SZ patients have more reductions while FEP-NSZ patients have more enhancements.
Conclusions: HC and FEP individuals exhibit distinct patterns of longitudinal connectomic changes in different brain regions, suggesting that different cortical regions could be influenced by disease outcome. FEP-SZ and FEP-NSZ individuals have distinct patterns of neuroanatomical alterations over time, with FEP-SZ patients having less optimal hubs over time. The clinical significance of these changes, i.e. how the connectomic changes relate to clinical changes remains to be determined.
Live Zoom Session – March 9th
Dung Hoang, BS, Victor Zeng, BS, Matcheri Keshavan, MD, Paulo Lizano, MD, PhD
Paulo Lizano, MD, PhD